Large Scale Molecular Modeling of Biomass and the Molecules that Torture It
Michael Crowley, senior scientist at the National Renewable Energy Laboratory (NREL) in Colorado, will speak as part of the 2010-11 EBI Seminar Series.
The abstract:
Modeling of cell wall components degrading enzymes has taken on an essential role in the search for both understanding of cell walls and cell wall digestion. Our research is directly connected to the experimental efforts at NREL to understand and design better enzymes, cellulosomes, and pretreatments. This presentation will highlight our work to understand cellulose microfibril shape and morphology, thermodynamics of decrystalization, cellulase processive digestion of cellulose, and cellulosome assembly and function. Our primary successes are to discover the internal hydrogen bonding networks in microfibrils at both room temperature and high temperature, determining both the thermodynamic price for decrystallization of cellulose, and the expulsion of cellobiose from Cel7A cellulase and to suggest ways to improve both the substrate and mutate the enzyme for more efficient digestion.
Patenaude will discuss his new book, Trotsky: Downfall of a Revolutionary, which describes Leon Trotsky's last years in Mexico in the late 1930s. At the center of this gripping and tragic story are Trotsky's tumultuous friendship with painter Diego Rivera; his affair with Rivera's wife, artist Frida Kahlo; and his torment as his family and comrades become victims of the Great Terror and Stalin's assassins close in.
Bertrand Patenaude is a research fellow at the Hoover Institution and a lecturer in History and International Relations at Stanford University. He is the author and editor of several books, including most recently Trotsky: Downfall of a Revolutionary (HarperCollins, 2009).