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14 Nov 2023 10:45:37 UTC
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How uric acid is metabolized
The process of uric acid metabolism involves several steps in the body, primarily occurring in the liver and the kidneys. Here's a simplified overview of how uric acid is metabolized:

Purine Metabolism:
Purines are natural substances found in the cells of the body and in certain foods. They are crucial for various cellular functions, including the formation of DNA and RNA.
When cells die or when certain foods are broken down, purines are released.

Formation of Uric Acid:
In the liver, purines undergo a series of enzymatic reactions, ultimately leading to the production of uric acid.
The enzyme xanthine oxidase plays a key role in this process by converting xanthine, an intermediate product in purine metabolism, into uric acid.

Transport in the Bloodstream:
Uric acid, being a water-insoluble compound, is not very soluble in the bloodstream. It is transported in the blood bound to proteins, particularly albumin.

Filtration in the Kidneys:
The bloodstream carries uric acid to the kidneys, where it undergoes the process of filtration.
In the kidneys, uric acid is filtered from the blood and enters the renal tubules.

Reabsorption and Secretion in the Kidneys:
Within the renal tubules, some uric acid is reabsorbed back into the bloodstream, while the rest is excreted into the urine.
Uric acid is reabsorbed through various transporters, and its secretion is regulated by different factors, including pH and the concentration of other substances in the urine.

Excretion in Urine:
The final step in uric acid metabolism is its excretion in the urine. The majority of uric acid is eliminated from the body through urine.
Factors such as hydration, kidney function, and the overall balance of purine metabolism influence the concentration of uric acid in the urine.


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