Author: Bernard Freydberg File Type: pdf Delving beneath the principal discourses of philosophy from Descartes through Kant, Bernard Freydberg plumbs the previously concealed dark forces that ignite the inner power of modern thought. He contends that reason itself issues from an implicit and unconscious suppression of the nonrational. Even the modern philosophical concerns of nature and limits are undergirded by a dark side that dwells in them and makes them possible. Freydberg traces these dark sources to the poetry of Hesiod, the fragments of Heraclitus and Parmenides, and the Platonic dialogues and claims that they rear their heads again in the work of Spinoza, Schelling, and Nietzsche. Freydberg does not set forth a critique of modern philosophy but explores its intrinsic continuity with its ancient roots.

Author: John Parrington File Type: pdf Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwins theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering. In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. Mutation chain reaction can be used to alter the genes of a population of pests, such as flies as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch. These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet. **Review a thorough and comprehensive account of the methodologies for altering life that have been or are being developed, and the directions that they may take in future. John Harris, Nature About the Author John Parrington, University Lecturer in Pharmacology, University of Oxford John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. He has also written science reports for the Wellcome Trust, British Council, and Royal Society. He is the author of The Deeper Genome, (OUP, 2015).