Published: January 15, 2023. Abstract: Optimal regeneration of skin lesions needs to ensure protection against opportunistic infections that may hinder the healing process or increase the risk of infection. The use of antibiotics to avoid infection can, in some cases, interfere with tissue regeneration, and often fails due to resistant bacterial strains. Thus, there is a need to expand the arsenal of safe and effective treatment options available. Here, we document the prevention of infections and tissue repair in skin lesions using treatments based on a chlorine dioxide solution. We document four case reports, that include an abdominal burn by a chemical agent, a palpebral burn by extreme heat, limb ulceration due to vascular insufficiency, and a melanoma of the scalp. All lesions were treated topically with a chlorine dioxide solution, and systemically when necessary, according to previously proposed protocols. All four patients showed complete dermal regeneration, with aesthetic results, no side effects or any evidence of adverse effects or interactions with the concomitant treatments used. The results constitute evidence that a topical or systemic solution of chlorine dioxide is safe as an antiseptic treatment in the adequate and swift resolution of skin lesions. Keywords: Chlorine dioxide solution; Oxidizing solutions; Skin lesions; CDS Manuel Aparicio-Alonso* Centro Médico Jurica, Querétaro, Mexico *Corresponding author: Manuel Aparicio-Alonso, Centro Médico Jurica, Querétaro, Mexico. E-mail: dr.aparicio.alonso@gmail.com Received: December 22, 2022; Accepted: January 03, 2023; Published: January 15, 2023 Source of the PDF: https://www.literaturepublishers.org/assets/images/articles/pNf0Sb_ziYD97_60HZa5_3mc6LU_399176.pdf If you want to download this video on Odysee: Click on the three dots below the video and then on "Download". Watch this video on Telegram: Additional information about CDS: https://andreaskalcker.com/ https://www.comusav.com/ Video collection about CDS, Chlorine Dioxide Solution (in English): https://odysee.com/@CDS-Chlorine-Dioxide:5 Video collection about CDS on Telegram (in English): https://t.me/CDS_ChlorineDioxide Video collection about CDS, Chlorine Dioxide in German language: https://odysee.com/@CDL:9 You Tube has deleted numerous scientific and medical videos about chlorine dioxide (ClO2) to hide the positive effects for humans and animals, because the cheap CDS is a thorn in the eye of the pharmaceutical industry with its expensive chemical products, which often do not heal, but only treat the symptoms or even harm. Therefore, the aim of this channel is to publish the scientific and medical facts about CDS so that the positive effects can be made known to a wide public and Fake News can be avoided. CDS is not MMS because CDS contains only the pure chlorine dioxide gas (ClO2) dissolved in water without other substances such as: Sodium chlorite (NaClO2), citric acid (C6H8O7) or hydrochloric acid (HCl). Important warning about Fake News: CDS is not bleach (sodium hypochlorite, NaClO) and not chlorine (Cl2), as is often falsely claimed in the media, but is composed of the two vital components namely the chloride ion (Cl-), which we also find in normal salt (Na+Cl-) and oxygen (O2). The positive anti-bacterial, anti-fungal and anti-viral effects result mainly from oxidation processes, because oxygen (O2) is the most important active component of the chlorine dioxide (ClO2) molecule. Therefore, CDS is gaining more and more importance in medicine and is used by thousands of doctors worldwide to cure patients with acute and chronic diseases, as traditional medicine often cannot help sufficiently. .