Poly-N-acetyl glucosamine (PNAG) is a broadly expressed surface or capsular polysaccharide detected on major bacterial and eukaryotic pathogens. Natural antibody to PNAG is generally poorly effective at mediating protection against infection, but by using modified glycoforms of the antigen antibodies can be elicited or selected from libraries that have the ability to kill target organisms facilitated by activation of the classical pathway of complement. Protective efficacy has been validated in a broad range of mouse systems of infection with different organisms and in pigs challenged with Actinobacillus pleuropneumoniae. The unexpected discovery by multiple investigators of a highly conserved surface antigen on most major pathogens, and means to engender effective immunity, opens up the potential for a single vaccine to provide partial or perhaps complete protection against many of the major infectious agents relevant to animal and human health.

The China-U.S. Climate Change Forum was organized by the Berkeley China Initiative, which is forging closer ties between U.C. Berkeley and China by bringing together key experts on important international and bilateral issues. Growing concern over climate change makes this topic an obvious choice for the first of this series of annual events. This panel highlights the mutual vulnerability of China and the U.S. to climate change, and the indispensable role of scientific research in understanding the problem and developing solutions. Panelists include: Robert Birgeneau, University of California at Berkeley; Richard Blum, UC Board of Regents; Steve Chu, Lawrence Berkeley National Laboratory; C.S. Kiang,...

Energy and Resources Group C200, 001 - Fall 2014 Energy and Society - Daniel M. Kammen Creative Commons 3.0: Attribution-NonCommercial-NoDerivs

eCHEM 1A: Online General Chemistry College of Chemistry, University of California, Berkeley http://chemistry.berkeley.edu/echem1a Curriculum and ChemQuizzes developed by Dr. Mark Kubinec and Professor Alexander Pines Chemical Demonstrations by Lonnie Martin Video Production by Jon Schainker and Scott Vento Developed with the support of The Camille & Henry Dreyfus Foundation