Agricultural and Resource Economics 213, 001 - Fall 2014
Applied Econometrics - Michael Anderson
Creative Commons 3.0: Attribution-NonCommercial-NoDerivs
Recent evidence suggests that a massive body is lurking at the outskirts of our solar system, far beyond the orbits of the known giant planets. This object, at a distance approximately 20 times further than Neptune and with a mass approximately 5000 times larger than Pluto, is the real ninth planet of the solar system. In his lecture, Mike Brown talks about the observation that led his team to the evidence for this Planet Nine and discusses how so massive an object could have been hiding in the outer solar system for so long. He also discusses the international effort to pinpoint this newest member of our planetary family.
Mike Brown is the Richard and Barbara Rosenberg Professor of Planetary Astronomy at the California Institute of Technology, specializing in the discovery and study of bodies at the edge of the solar system. He is best known for his discovery of Eris, the most massive object found in the solar system in 150 years, which led to the debate and eventual demotion of Pluto from a real planet to a dwarf planet. In 2006 he was named one of Time Magazine's 100 Most Influential People and was inducted into the National Academy of Sciences in 2014.
eCHEM 1A: Online General Chemistry
College of Chemistry, University of California, Berkeley
http://chemistry.berkeley.edu/echem1a
Curriculum and ChemQuizzes developed by Dr. Mark Kubinec and Professor Alexander Pines
Chemical Demonstrations by Lonnie Martin
Video Production by Jon Schainker and Scott Vento
Developed with the support of The Camille & Henry Dreyfus Foundation
The advent of high-throughput genome sequence analysis has enabled systematic discovery of somatic genome alterations through genome, exome, and transcriptome sequencing of paired human cancer and germline nucleic acids. These discoveries have led to the identification of somatic genome alterations in new pathways including epigenetic regulators, RNA splicing factors, and immune response regulators, in addition to previously known signal transduction, cell cycle, and transcriptional pathways. I will discuss alterations in these pathways by copy number disruption, mutation, and re-arrangement, especially as seen through the lens of recent and ongoing large- scale studies of lung adenocarcinoma and squamous cell lung carcinoma genomes, from The Cancer Genome Atlas and beyond—and will discuss the implications for the understanding of cancer pathogenesis and for the development of targeted and im- munomodulatory therapies.