James Heller goes on a quest to destroy the Blacklight virus. The story is one of revenge, as Heller wants to kill Alex Mercer, protagonist of the original Prototype, after his family was killed in the outbreak of the Blacklight virus.
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https://www.youtube.com/watch?v=LVlbTZVQYSA
Going to lost city, finding a dead Progenator, absorbing its energy into the ASE to finally have enough power to take down Adams
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https://www.youtube.com/watch?v=uV4yMzPxKtw
Completing the Ice Cavern, getting the Iron boots, learning the Seranade of water from Shriek and getting the Zora tunic from King Zora
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https://www.youtube.com/watch?v=aKuJgvIuUYI
Joker and Harley climb the tower and are finally able to start the Joker's master plan of gassing the city
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https://www.youtube.com/watch?v=TarfxQzwDqg